To directly address a role of Schwann cell-derived NRG1 in CMT1A models, we ablated Nrg1 in Schwann cells from CMT1A mice by breeding to conditional DhhCre::Nrg1-flox mutants (FVB(Cg)-Tg(Dhh-cre)1Mejr/J, [DhhCre]32 and Nrg1tm3Cbm [Nrg1fl/fl]33, NRG1cKO mice), termed CMT1A-NRG1cKO mice. The gene discussed is PMP22; the disease is Charcot-Marie-Tooth disease type 1A.