Here we propose a model according to which Pmp22 overexpression compromises axo-glial NRG1 signaling in early CMT1A disease that results in functionally denervated Schwann cells that respond with aberrant glial NRG1-I induction (see model, Supplementary Fig. 4). The gene discussed is NRG1; the disease is Charcot-Marie-Tooth disease type 1A.