PPARGC1A and steatosis: In turn, acetylation of SIRT1 target transcriptional regulators (peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), sterol regulatory element-binding protein-1c (SREBP-1c), farnesoid X receptor (FXR), and nuclear factor-κb (NF-κB)) increases, causing steatosis, inflammation, and impaired glucose tolerance.