Mechanistic studies have found that lncSHGL recruits heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, and inhibits the mTOR / SREBP-1C pathway, thus ameliorating hyperglycemia and steatosis in obese mice. This evidence concerns the gene HNRNPA1 and Hyperglycemia.