CD274 and metastatic melanoma: Ultimately, whilst PD-L1 status has been shown to correlate with response to treatment with anti-PD-1 antibodies in metastatic melanoma in some studies (9, 10), the expression of PD-L1 per se has not emerged as a predictive marker for treatment response, potentially due to its crucial role in engaging PD-1, a dominant negative regulator of anti-tumor T cell effector function (1, 9, 11).