Mechanistically, several membrane-associated proteins such as Nf2/Merlin, scaffolding proteins of the angiomotin family, and WWC proteins have been shown to positively and – for certain members of the angiomotin family – negatively regulate Hippo signaling (Zhang et al., 2010; Li et al., 2012; Yi et al., 2013; Moleirinho et al., 2017; Hermann et al., 2018) – however, the relevance of these proteins in cirrhosis is unknown to date. This evidence concerns the gene NF2 and Cirrhosis.