Interestingly, inactivating mutations in the negative Wnt regulator AXIN do not lead to increased Wnt/β-catenin signaling in hepatocellular carcinoma as would be expected, but are instead associated with a proliferative phenotype and gene signatures enriched for Notch and YAP signaling indicating for a Wnt-independent direct or indirect inhibition of YAP by AXIN (Abitbol et al., 2018). The gene discussed is AXIN1; the disease is hepatocellular carcinoma.