Several studies showed that YAP/TEAD co-operate with E2F transcription factors downstream of retinoblastoma signaling to promote proliferation in cancer, including in liver cancer (Ehmer et al., 2014; Kapoor et al., 2014; Ehmer and Sage, 2015; Fitamant et al., 2015; Hiemer et al., 2015; Shi et al., 2016). This evidence concerns the gene YAP1 and cancer.