In the same line, hepatic inactivation of the MST1/2-adaptor protein SAV1/WW45 resulted in YAP-associated cell proliferation and mutant mice ultimately developed tumors with characteristics of HCC and intrahepatic cholangiocarcinomas (ICC) (Lee et al., 2010; Lu et al., 2010). Here, SAV1 is linked to hepatocellular carcinoma.