YAP1 and hepatocellular carcinoma: Aside from proliferation, YAP signaling in HCC is involved in a multitude of cancer-associated pathways, including suppression of apoptosis, deregulated ER/unfolded protein response, and chromosomal instability (CNI) (Rosenbluh et al., 2012; Wu et al., 2015; Weiler et al., 2017).