LRP1 and early-onset autosomal dominant Alzheimer disease: Lrp1 is vital for the production, internalization and catabolism of amyloid β (Kounnas et al., 1995a; Knauer et al., 1996; Pietrzik et al., 2002; Deane et al., 2004, 2008; Lillis et al., 2008) (Figure 5, 6), and in the brains of Alzheimer’s disease patients, according to some studies, Lrp1 levels are significantly reduced (Kang et al., 1997, 2000; Jaeger and Pietrzik, 2008; Shinohara et al., 2017).