Improper tPA-Lrp1 and tPA-Mac-1-Lrp1-PDGFR α interactions at the BBB are known to influence the permeability of the neurovascular unit in relation to seizures and ischemia (Polavarapu et al., 2007; Zhang et al., 2007, 2009; Su et al., 2008; Nakajima et al., 2014; Fredriksson et al., 2015). The gene discussed is LRP1; the disease is ischemia.