TPA, alike Lrp1, is implicated in the pathology of neurodegenerative diseases, including Alzheimer’s disease, psychotic disorders like schizophrenia (Fabbro and Seeds, 2009; Hoirisch-Clapauch and Nardi, 2015) and is recognized for supporting BBB integrity (Polavarapu et al., 2007; Fredriksson et al., 2015; Stefanitsch et al., 2015). Here, LRP1 is linked to early-onset autosomal dominant Alzheimer disease.