The studies of Liu et al. (2010) and Liu et al. (2011) additionally provide evidence for the importance of Lrp1 in maintaining proper brain lipid metabolism and leptin signaling and define Lrp1 as a major apolipoprotein E (ApoE) transport receptor, strengthening the role of Lrp1 in Alzheimer’s disease pathogenesis. This evidence concerns the gene LRP1 and early-onset autosomal dominant Alzheimer disease.