The deletion of Lrp1 from smooth muscle cells also impacts the integrity of the vasculature by altering PDGFR β signaling and levels of various ECM molecules pivotal for proper vessel development, contributing to the development of hypertension, atherosclerosis and other cardiovascular diseases (Zhou et al., 2009; Strickland et al., 2014). The gene discussed is LRP1; the disease is atherosclerosis.