NCAM1 and T-cell non-Hodgkin lymphoma: In a recent gene expression profiling and cytogenetic analysis, primary EBV-positive nodal T/NK-cell lymphoma showed a distinct molecular signature characterized by upregulation of PD-L1 and T-cell-related genes, including CD2 and CD8, and downregulation of CD56, compared to extranodal NK/T-cell lymphoma (131).