Two-thirds of the patients were aged ≥50 years (65.2%, n = 8,652), and the group comprised 8,936 (67.4%) non-Hispanic white patients, 9,075 (68.4%) patients with T2 stage cancer, 9,202 (69.4%) patients with N2 stage cancer, 8,161 (61.5%) ER+ and PR+ patients, and 8,316 (62.7%) married patients. The gene discussed is ESR1; the disease is cancer.