CD274 and gastric neoplasm: This classification was initially proposed in melanoma by Teng et al. (37) but has recently also been applied in gastric tumours in a study by Cho et al. (n = 247) wherein the PD-L1 TC positive/TIL positive TME subgroup, was found to be more frequent in EBV-positive and MSI-H gastric tumours and also to be associated with a favourable prognosis (38).