Interestingly, in pediatric LGGs, FGFR1 levels were higher than in HGGs in 2D monolayers but in 3D environments activated FGFR1 levels were higher in the highly migratory SF188 suggesting differential roles of FGFR1 signaling among low and high grade gliomas depending on the microenvironment. This evidence concerns the gene FGFR1 and central nervous system cancer.