IGHE and allergic disease: Previous studies evaluated serum IgE levels and investigated their relationship with a wide range of allergic diseases, including allergic contact dermatitis, allergic rhinitis, allergic urticaria and non-specific allergy in tannery workers.18 In light of the difficulties in obtaining immunological data for tannery workers, the present study was undertaken to evaluate the humoral or soluble immune function in Cr-exposed tannery workers in Bangladesh.