In Western countries, the normal serum concentration of IgE is 0–200 IU/mL, whereas in tropical countries this level may vary up to 2000 IU/mL.21 A previous study suggested that bronchial reactivity can develop after exposure to fumes from metal plating with Cr and nickel, and an IgE response may be seen even in previously non-allergic individuals.28 Studies have reported a prevalence of various allergic diseases among tannery workers in Bangladesh, and serum IgE levels were significantly higher in the occupationally-exposed tannery workers.6,18. This evidence concerns the gene IGHE and allergic disease.