SNCA and Lewy body dementia: In DLB, there is an accumulation of clumps of alphasynuclein (Lewy bodies) in the neurons, first described in 1912 by Friedrich Lewy.4 Typical Parkinsonian symptoms in DLB include reduced facial expression, stiffness, shuffling gait with minimal arm swing, dysphonia, dysphagia and hypersalivation, whilst tremors are less common.