Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by recurrent venous and/or arterial thrombotic events and/or obstetric complications and the presence of antiphospholipid antibodies (aPL) including anti-cardiolipin antibodies (aCL), anti-beta2-glycoprotein I antibodies (anti-β2GPI), and lupus anticoagulant (LA) (1). The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.