Moreover, based on TLR10 and TLR2 co-transfection or co-depletion through siRNA and effect on HIV-1 infection or integration, TLR10 appears to play a role in HIV-1 infection and integration independent of TLR2 since no additive effect of TLR10 and TLR2 was observed (Figures 3B,C). The gene discussed is TLR2; the disease is HIV-1 infection.