TLR1 and HIV-1 infection: In order to observe the HIV-1 infection in susceptible cells, macrophages were differentiated from THP-1 cells to determine whether siRNA-mediated knockdown of TLR1, 2 and/or 10 for 2 days prior to CCR5-tropic HIV-1 (BAL strain) exposure for 7 days would affect the HIV-1 infection rate.