Of particular significance for cancer immunotherapy, two isoforms of the low and intermediary affinity antibody checkpoints FcγRIIa (H131R) and FcγRIIIa (V158F), which bind IgG and antibody-coated target cells with higher affinity and avidity, have been associated with improved survival of diverse cancer patients in response to antibody-based cancer immunotherapy (35–39). Here, FCGR3A is linked to cancer.