Based on the significant upregulation of the sole inhibitory antibody checkpoint FcγRIIB in the tumor microenvironment (97), and its documented role in conferring resistance to antibody-based therapy in this niche (65, 70, 97), we have pursued antibody-mediated blockade of FcγRIIB as an alternative and complementary approach to Fc-engineering to harness the full potential of antibody checkpoint-regulated immunity. This evidence concerns the gene FCGR2B and neoplasm.