Highest and most homogenous expression of FcγRIIB is observed in Chronic Lymphocytic Leukemia (CLL), Mantle cell lymphoma (MCL), and Marginal Zone Lymphoma, although a fraction of Follicular lymphoma (FL) and Diffuse Large B cell Lymphoma show exceptionally high FcγRIIB expression (67, 68). This evidence concerns the gene FCGR2B and B-cell chronic lymphocytic leukemia.