Comparison of IFN-α levels in the supernatants of VSV-infected Wt and TLR7−/− BM-derived cell types at 6 and 18 h p.i. revealed that Wt and TLR7−/− pDC with strong VSV-luciferase expression at 6 h p.i. both failed to produce detectable IFN-α at this time point of infection (data not shown). The gene discussed is TLR7; the disease is infection.