In order to explore if IL-2 delivery can induce the accumulation of Foxp3+ Treg in the colons of mice during experimental colitis, we treated wild-type C57BL/6J mice with IL-2/JES6-1 immunocomplexes beginning at the time of DSS administration (day 0) and continuing every 2 days. Here, FOXP3 is linked to colitis.