In this report, we show that treatment of mice with IL-2/JES6-1 immunocomplex during DSS-induced colitis promoted Foxp3+ Treg expansion, but also potently stimulated GATA3+ group 2 innate lymphoid cell (ILC2) proliferation and high-level expression of IL-5 in the colon. The gene discussed is GATA3; the disease is colitis.