In light of these findings, we further demonstrated that combined IL-2/JES6-1 immunocomplex and anti-IL-5 mAb treatment was most effective at ameliorating DSS-induced colitis compared to either treatment alone and that this regimen allowed for Foxp3+ Treg expansion without concomitant eosinophilia. This evidence concerns the gene FOXP3 and Increased total eosinophil count.