For those patients with a suboptimal response to non-biologic DMARDs, in particular those with polyarthritis, the usage of biologic drugs such as tumor necrosis factor-α (TNF-α) inhibitors (etanercept, infliximab and adalimumab), IL-1 inhibitors (anakinra, canakinumab, and rilonacept), IL-6 inhibitor (tocilizumab), CD20/B-cell targeted (rituximab) and T-cell co-stimulatory signal blocker (abatacept), has been proven to be effective (19–22). The gene discussed is TNF; the disease is polyarticular arthritis.