For this purpose, we isolated MNC from freshly resected liver LN collected during liver transplant procedures from explant livers of patients with primary sclerosing cholangitis or auto-immune hepatitis, and compared relative numbers of the different APC subsets within CD45+ MNC with those in liver LN isolated from healthy livers of multi-organ donors. The gene discussed is PTPRC; the disease is sclerosing cholangitis.