In logistic regression models adjusted by vaccine, age, site and M0, among other variables when relevant, M3 IgG1 to AMA1 and RH1, IgG2 to AMA1 3D7, RH1 and RH5, and IgG3 and IgG4 to MSP2 FL CH150, were associated with increased malaria risk (Figure 7). The gene discussed is IGHG3; the disease is malaria.