SGCG and neoplasm: As pDCs are the main source of Type I and Type III interferons among all DC subsets (Table 1) and cDC1s hold great importance in CD8+ T cells mediated anti-tumor function in vivo, these results may also point out that the hypoxia condition in the micro-environment of tumor mass may suppressed the expansion and function of the DC subsets which promote anti-tumor processes.