Data indicating that cytosolic Mtb co-localizes with the components of autophagic machinery, i.e., p62 and LC3, was evident in only 30% of total Mtb phagosomes (Watson et al., 2012), providing evidence for the idea that the majority of intracellular Mtb might stop the activation of xenophagy due to a downregulation of TFEB nuclear translocation by mTOR activation during infection. This evidence concerns the gene MTOR and infection.