CXCL12 and breast neoplasm: Human lung and breast tumors have been shown to express higher CCL19 (a CD56bright cell attracting chemokine) and lower CXCL12 compared to their normal tissue counterpart (96), while in mice, BM with MM showed increased CXCL9 and CXCL10, decreased CXCL12, down-modulation of CXCR3 on NK cells, and selective reduction of KLRG1− cytotoxic NK cells (97).