<b>Results:</b> The pooled results of meta-analysis showed that elevated expression of SIRT1 implies a poor overall survival (OS) of cancer patients [Hazard Ratio (HR) = 1.566, 95% CI: 1.293-1.895, <i>P</i> < 0.0001], disease free survival (DFS) (HR = 1.631, 95% CI: 1.250-2.130, <i>P</i> = 0.0003), event free survival (EFS) (HR = 2.534, 95% CI: 1.602-4.009, <i>P</i> = 0.0001), and progress-free survival (PFS) (HR = 3.325 95% CI: 2.762-4.003, <i>P</i> < 0.0001). The gene discussed is SIRT1; the disease is cancer.