Gold standard. Higher accuracy and reproducibility and lower variability than echocardiography (71, 72). Myocardial transverse relaxation time (T2) allows a non-invasive assessment for detecting myocardial edema, and thus the direct action of GH and IGF-1 on the heart. Serves to evaluate the efficacy of acromegaly treatment regarding cardiomyopathy (35). Here, IGF1 is linked to acromegaly.