Recently proposed instruments such as SAGIT (Signs and symptoms, Associated comorbidities, GH levels, IGF1 levels and Tumor profile) (13) and ACRODAT (Acromegaly Disease Activity Tool) (14), in addition to routine diagnostic methods, could possibly be used to specifically evaluate the presence of these comorbidities at the time of diagnosis of acromegaly, and also during follow-up (15). The gene discussed is IGF1; the disease is acromegaly.