TLR4 and Hypertension: LPS might be involved in the pathogenesis of hypertension, through toll-like receptor (TLR)-4 stimulation in the vasculature (Liang et al., 2013), and by inducing systemic inflammation, accompanied by microglia activation, oxidative stress in cardiovascular regions of the brain, such as rostral ventrolateral medulla (Wu et al., 2012) and PVN (Zhang et al., 2010).