Mostafavi et al. (2018) applied a network-based method and identified specific genes that were associated with AD-related traits. By integrating clinical, neuropathology and gene expression data, they detected a co-expression module which is related to both cognitive decline and β-amyloid burden. Furthermore, they identified two genes in the module, INPPL1 and PLXNB1, as potential AD therapeutic targets. The gene discussed is PLXNB1; the disease is Alzheimer disease.