In addition, it has been demonstrated recently that Wfs1 forms a complex with neuronal calcium sensor 1 (NCS1) and inositol 1,4,5-trisphosphate receptor (IP3R) to promote Ca2+ transfer between the ER and mitochondria in WS patient fibroblasts (Angebault et al., 2018). The gene discussed is WFS1; the disease is Werner syndrome.