However, it is possible to speculate that, because 8-OH-dG sequesters NLRP3 (Eltom et al., 2014), it is likely that this receptor is not responsive in COPD-derived PBMCs, which have higher basal levels of 8-OH-dG, marker of DNA damage associated to oxidative stress, one of the main feature of chronic inflammation in COPD (Colarusso et al., 2017). This evidence concerns the gene NLRP3 and chronic obstructive pulmonary disease.