Because AIM2 recognizes cytosolic dsDNA (Jin et al., 2012; Terlizzi et al., 2014), in order to understand the relationship between oxidative stress, crucial in the lung of COPD patients (Faner et al., 2016; Colarusso et al., 2017), and AIM2, we analyzed the levels of 8-OH-dG, which is a marker for oxidative stress to DNA (Halwani et al., 2011; De Falco et al., 2017a). The gene discussed is AIM2; the disease is chronic obstructive pulmonary disease.