AIM2 and chronic obstructive pulmonary disease: Basal levels of 8-OH-dG, marker of DNA oxidative stress (Valavanidis et al., 2009; Halwani et al., 2011; De Falco et al., 2017a), were higher in COPD-derived PBMCs than healthy non-smokers and smokers, implying that DNA damage during the pro-inflammatory patterns, could boost AIM2 activation in these patients.