To note, stable COPD-derived PBMCs were not responsive to Poly dA:dT in that they showed no significant release of IL-1α (ctr: 23.61 ± 0.569 vs. dA:dT: 26.4 ± 0.872) compared to unstable COPD-derived PBMCs (ctr: 37.39 ± 5.486 vs. dA:dT: 234.9 ± 30.75; Figure 2C). This evidence concerns the gene IL1A and chronic obstructive pulmonary disease.