Genetically engineered mouse models designed to recapitulate genetic and pathologic aspects of pancreatic ductal adenocarcinoma (PDAC) are the LSL-KrasG12D/+;Pdx-1-Cre (KC) and LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) mice, in which the Cre-recombinase, transcribed by the pancreas-specific Pdx-1 promoter, leads to the expression of oncogenic mutant for of Kras alone or in combination with a mutant p53 protein, respectively (Hingorani et al., 2003, 2005). This evidence concerns the gene PDX1 and pancreatic ductal adenocarcinoma.