If these results could be generalized they may be relevant to further understand the physiopathological relevance of the expression of dominant-negative GR isoforms, such GR-beta (Yudt et al., 2003; Lewis-Tuffin and Cidlowski, 2006), which has been associated with decreased GC responsiveness and susceptibility to develop autoimmune diseases (Tait et al., 2008). This evidence concerns the gene NR3C1 and autoimmune disease.