Key cytokines in the pathogenesis of IBD belong to Type I and Type II cytokines receptors [i.e., IL-6, IL-5, IL-9, IL-10, IL-13, IL-12/23, IL-22, granulocyte–macrophage colony-stimulating factor (GM-CSF), IFN-γ] (Zhou et al., 2007; Dienz and Rincon, 2009; Abbas et al., 2014a,c; Flamant et al., 2017). This evidence concerns the gene IL22 and inflammatory bowel disease.