SLC6A4 and major depressive disorder: We also demonstrated that MPC patterns of SERT, 5HT2AR, dopamine transporter, and NMDA receptor 2B subunit, indicate an increase in cluster size but not in cluster number, while MPC analysis of beta-adrenergic receptor 2 gives rise to a decrease in receptor cluster size but no changes in numbers, and MPC study of pannexin 1 and prion cellular protein indicates that both the number and size of clusters are increased in the repeated-corticosterone model of depression (Romay-Tallon et al., 2018).