At the same time, studies on animal models of depression provided numerous evidences that reelin downregulation in the subgranular zone of the dentate gyrus may affect the maturation of dentate newborn neurons (Lussier et al., 2009, 2013a) and dysregulate the glutamatergic-GABAergic systems crosstalk in limbic brain areas (Lussier et al., 2013b). Here, RELN is linked to major depressive disorder.