We were surprised to find that measurements of 5HT2A clustering patterns in lymphocytes from naive MDD patients not only allowed us to again differentiate two patient subpopulations according to the distribution of 5HT2A cluster size, but that the same patients who were characterized as D-I and D-II when studying SERT clustering parameters (see above) were similarly shown as D-I or D-II when analyzing the characteristics of 5HT2A clusters and logically gave rise to a similar differential response to treatment (Rivera-Baltanas et al., 2014). Here, HTR2A is linked to major depressive disorder.