We focused on the study of the patterns of SERT clustering in depression patients in relation to a scale that measures anhedonia symptoms, because anhedonia is not only considered a key symptom of depression (APA, 2013) but is also conceptualized as a specific endophenotype of MDD (Pizzagalli, 2014) and a predictor of treatment response (Spijker et al., 2001). Here, SLC6A4 is linked to major depressive disorder.