We hypothesized that in naïve depression patients (i.e., patients who had not taken antidepressants at least for several months) the pattern of SERT clustering in lymphocytes would follow the lines of that observed in heterozygous reeler mice (i.e., the average SERT cluster size would be larger in depression patients than in normal controls) and that response to antidepressant medication would be followed by a reversal of the alterations in the pattern of SERT clustering. The gene discussed is SLC6A4; the disease is major depressive disorder.