RELN and major depressive disorder: Reelin haploinsufficient heterozygous reeler mice show some subtle alterations in neurochemistry and behavior, but otherwise are almost indistinguishable from wild-type mice; however, we have found that these animals are extremely susceptible to the depressogenic effects of repeated subcutaneous injections of the stress hormone corticosterone and show depressive-like behavioral paradigms at corticosterone doses that fail to induce such behaviors in wild-type mice, which prompted us to consider reelin downregulation as a putative vulnerability factor for depression (Lussier et al., 2011).