The significant regressors for the prediction of ΔMDS-UPDRS2 in the PD no med group were GM volume in the premotor and prefrontal cortex, putamen DAT-SPECT, FA in the pontine tegmentum and the interaction between DAT signal in the putamen – GM volume in premotor, prefrontal cortex and insula (Tables 3, 4). Here, SLC6A3 is linked to Parkinson disease.