Moreover, AD brain micro-vessels express significantly higher amount and range of inflammatory mediators such as thrombin, nitric oxide, transforming growth factor-β, TNF-α, IL-1β, IL-6, IL-8 and MMPs (Dorheim et al., 1994; Grammas and Ovase, 2001, 2002; Thirumangalakudi et al., 2006). This evidence concerns the gene TNF and Alzheimer disease.