PPARG and Alzheimer disease: We and others have demonstrated that PPARγ agonism improves hippocampus-dependent cognitive performance in Alzheimer’s disease (AD) mouse models, predominantly in tasks that require intact hippocampal ERK signaling (Pedersen et al., 2006; Escribano et al., 2009; Rodriguez-Rivera et al., 2011; O’Reilly and Lynch, 2012).