SLC6A3 and Parkinson disease: By using a Dat driven Cre, Lmx1b was removed in postmitotic mdDA neurons, which led to dysregulation of the autophagic-lysosal pathway, abnormal synaptic responses and reduced protein levels of striatal TH and DAT expression, all processes that contribute to a Parkinson’s disease pathology (Laguna et al., 2015).