For example, antiinflammatory drugs, such as indomethacin and a selective COX-2 inhibitor etoricoxib, may decrease not only the LPS-induced increase in SWD number (indomethacin) but also spontaneous absence seizures (indomethacin and etoricoxib) (Kovács et al., 2006, 2011, 2014a; Citraro et al., 2015), whereas etoricoxib evoked long-lasting antiepileptogenic effects likely by inhibition of background inflammatory processes (Citraro et al., 2015). This evidence concerns the gene PTGS2 and Generalized non-motor (absence) seizure.