NOD-like receptor pyrin domain 3 (NLRP3) inflammasome is a multiprotein complex containing NOD-like receptor (NLRP3), an adaptor protein (ASC: apoptosis-associated speck-like protein containing a caspase recruitment domain) and a cysteine protease (caspase-1) (de Rivero Vaccari et al., 2014; Levy et al., 2015), which has a role in the pathophysiology of several CNS diseases, such as epilepsy (Edye et al., 2014; Simeone et al., 2018). Here, CTSB is linked to epilepsy.