To identify the role of Arc in regulating the DSS-mediated effects on CCH-induced injuries, Ad-NC, Ad-Arc, or Ad-shArc was injected into the hippocampus of 2VO rats treated with 0.4 mg/kg DSS or used to infect OGD-cultured primary hippocampal neurons treated with DSS (10 μmol). Here, ARC is linked to columnar cell hyperplasia of the breast.