However, it has also been shown thatCXCR7 inhibits metastasis by interfering with CXCR4–CXCL12 interaction and silencing of CXCR7 in endothelialcells results in recurrence and increased metastasis, pointingto a tumour-suppressor role of CXCR7(Hernandez etal., 2011; Stacer et al., 2016). This evidence concerns the gene CXCR4 and neoplasm.