Meanwhile, after using siRNAPVT1, not only was the expression level of lncRNA PVT1and c-Myc mRNA downregulated, but the protein levelof the c-Myc onwcogene was also remarkably reduced.The presence of lncRNA PVT1 is an indispensable partof c-Myc expression, so the upregulation of lncRNA invarious cancers preserves c-Myc phosphorylation and thesubsequent degradation of this oncogene(Hamilton et al.,2015), which our findings confirmed. The gene discussed is MYC; the disease is cancer.