Since previous studies have indicated that both AT1 receptor antagonists and inhibitors of angiotensin‐converting enzyme improve the endothelial function in type 2 diabetic patients and in experimental models of diabetes 33, 34, 35 and that Ang II is a strong inducer of endothelial senescence,36 experiments were performed to determine the role of the local angiotensin system in HG‐induced endothelial senescence and its modulation by empagliflozin. This evidence concerns the gene AGTR1 and type 2 diabetes mellitus.