ACE and diabetes mellitus: Since previous studies have indicated that both AT1 receptor antagonists and inhibitors of angiotensin‐converting enzyme improve the endothelial function in type 2 diabetic patients and in experimental models of diabetes 33, 34, 35 and that Ang II is a strong inducer of endothelial senescence,36 experiments were performed to determine the role of the local angiotensin system in HG‐induced endothelial senescence and its modulation by empagliflozin.