The early seizure variant (Hanefeld variant), associated with CDKL5 mutations, is characterized by seizure onset before 5 months of age, usually with infantile spasms (50%) and refractory myoclonic epilepsy (25%) (Dolce et al., 2013; Pintaudi et al., 2010). This evidence concerns the gene CDKL5 and infantile spasms.