MECP2 and epilepsy: Reviewing literature, beyond the age of onset, other factors have been identified as risk factors for epilepsy and its severity: microcephaly (Steffenburg et al., 2001), developmental delay in the first 10 months of life, and absence of walking (Jian et al., 2006), certain mutations in the MECP2 gene with regard to classical form (Glaze et al., 2010).