NFE2L2 and skin neoplasm: The aggravated oxidative stress caused by quinone rendered the Nrf2‐deficient mice to be more prone to skin cancer, while the expression of NQO1 and GST regulated by Nrf2 decreased when compared to wild‐type mice.62 Similarly, Nrf2‐deficient mice treated with carcinogens develop the much larger number of tumors in the forestomach,63 liver,64 and urinary bladder65 compared with that of the wild‐type mice, suggesting that Nrf2 protects against inflammation‐induced carcinogenesis.