NFE2L2 and neoplasm: In tumor microenvironment, Nrf2 is activated by tumor suppressor genes BRCA1 and protein p21 via the inhibition of Keap1/Nrf2 complex formation59, 60 and is blocked by oncogene Fyn‐mediated degradation.61 The expression of antioxidant and phase II enzymes was found to be abrogated in the Nrf2‐deficient mice.