BCL2 and neoplasm: Another study suggested that the spatial proximity of breast ductal carcinoma cells to CAFs also influences lapatinib resistance, as the induction of antiapoptotic Bcl-2/Bcl-x, PI3K/AKT ,and JAK/STAT signaling was observed in lapatinib-treated tumor cells, and this induction was associated with CAF-induced protection by HA in the stroma and with intercellular communication between tumor cells and CAFs through JAK/STAT signaling [102].