The HIF-1α-binding sequence in A375 melanoma cells, U251 glioblastoma cells, HCT116 colon cancer cells, A375 cell xenografts, and clinical breast cancer samples directly increased the transcription of miR-424, which suppressed the levels of the apoptosis-associated factor PDCD4 and protected cells from apoptosis [76]. Here, HIF1A is linked to glioblastoma.