Trimaco et al. also proved that MSCs isolated from the bone marrow of CLL patients rendered CLL B cells resistant to fludarabine in coculture conditions, which could be related to the presence of cytoprotective cytokines such as IL-8, CCL4, CCL11, and CXCL10 [67]. This evidence concerns the gene CCL4 and B-cell chronic lymphocytic leukemia.