pSTAT3 is translocated to the nucleus to regulate expression of a number of miRNAs, including miR-506-3p, which facilitates the EMT program to mediate MCTC generation, thereby enhancing the migration, invasion, and metastatic potential of CRC cells through miR-506-3p/FoxQ1 axis. This evidence concerns the gene FOXQ1 and colorectal carcinoma.