The results found that the stimulation of CRC cells with IL6 or co-cultured with TAMs increased the expressions of p-JAK2 and p-STAT3, whereas the treatment of IL6 neutralizing antibody inhibited co-cultured-induced expressions of p-JAK2 and p-STAT3 (Fig. 4A). The gene discussed is JAK2; the disease is colorectal carcinoma.