Although MDSCs have been first discovered for their immune-suppressive function in cancer, recently the presence of MDSCs has also been linked to other processes within the TME, such as promotion of tumor angiogenesis via production of pro-angiogenic factors [94, 95], degradation of ECM via production of significant levels of MMPs, especially MMP-9, and most importantly the formation of premetastatic niches. The gene discussed is MMP9; the disease is neoplasm.