TGFB1 and neoplasm: Suggested mechanisms, by which platelets promote extravasation and transendothelial migration, include induction of the EMT and invasiveness in tumor cells via TGF-β-mediated activation of Smad and NF-κB signaling pathways [410], as well as modulation of endothelial junctions and cytoskeleton via ATP secreted by platelets after tumor cell activation, which interacts with endothelial P2Y2 receptor in order to open the EC junctions [411].