Their results suggest that interactions αvβ3-osteopontin, αvβ3-fibronectin and α5β1-fibronectin play a role in HNSCC angiogenesis and interactions α5β1-fibronectin and αvβ5-vitronectin in HNSCC cancer cell behavior [287]. This evidence concerns the gene SPP1 and head and neck squamous cell carcinoma.