STUB1 and neoplasm: Among the positive clones independently isolated from the HeLa cell cDNA library, we focused particularly on CHIP because this protein has been identified as a tumor suppressor that can induce the ubiquitylation and degradation of several oncogenic proteins (Jang et al., 2011; Kajiro et al., 2009; Kao et al., 2014; Paul et al., 2013; Tateishi et al., 2004; Wang et al., 2013; Xu et al., 2002).