CHIP functions as a tumor suppressor by catalyzing the ubiquitylation and degradation of several oncogenic proteins, including ErbB2 (Xu et al., 2002), estrogen receptor α (Tateishi et al., 2004), Met receptor (Jang et al., 2011), c‐Myc (Paul et al., 2013), NF‐κB (Wang et al., 2013), and Slug (Kao et al., 2014). This evidence concerns the gene STUB1 and neoplasm.