It was shown that at a blood concentration of approximately 4 μM (75 mg VOSO4 daily, route of administration: oral 5 mg/day/kg body weight VOSO4) was not toxic, even after 6-week therapy of patients with type 2 diabetes mellitus (T2DM) [33, 34] or supplementation with insulin through 2.5 years of therapy of patients with type 1 diabetes mellitus (T1DM) [32]. Here, INS is linked to type 2 diabetes mellitus.