Previous studies showed that activation of TNFR2 induces the AKT/ERK signaling pathway and promotes tumorigenesis [27], and we also confirmed that the AKT/ERK signaling pathway was inhibited after TNFR2 knockdown in pancreatic cancer (Fig. 4i, Figure S2b, c). This evidence concerns the gene AKT1 and familial pancreatic carcinoma.