Whereas local connectivity in the hippocampus was well preserved in APP/PS1 mice, impaired hippocampal – medial frontal cortical coupling was evident in APP/PS1 mice at an age (5–6 months) when amyloid pathology is present in the cortex and hippocampus16 but memory impairment has not become manifest in behavioral tasks19. This evidence concerns the gene APP and memory impairment.